Archive for Montpellier

Methodological developments in evolutionary genomic [3 years postdoc in Montpellier]

Posted in pictures, Statistics, Travel, University life, Wines with tags , , , , , , , , , on November 26, 2014 by xi'an

[Here is a call for a post-doctoral position in Montpellier, South of France, not Montpelier, Vermont!, in a population genetics group with whom I am working. Highly recommended if you are currently looking for a postdoc!]

Three-year post-doctoral position at the Institute of Computational Biology (IBC), Montpellier (France) :
Methodological developments in evolutionary genomics.

One young investigator position opens immediately at the Institute for Computational Biology (IBC) of Montpellier (France) to work on the development of innovative inference methods and software in population genomics or phylogenetics to analyze large-scale genomic data in the fields of health, agronomy and environment (Work Package 2 « evolutionary genomics » of the IBC). The candidate will develop its own research on some of the following topics : selective processes, demographic history, spatial genetic processes, very large phylogenies reconstruction, gene/species tree reconciliation, using maximum likelihood, Bayesian and simulation-based inference. We are seeking a candidate with a strong background in mathematical and computational evolutionary biology, with interest in applications and software development. The successfull candidate will work on his own project, build in collaboration with any researcher involved in the WP2 project and working at the IBC labs (AGAP, CBGP, ISEM, I3M, LIRMM, MIVEGEC).

IBC hires young investigators, typically with a PhD plus some post-doc experience, a high level of publishing, strong communication abilities, and a taste for multidisciplinary research. Working full-time at IBC, these young researchers will play a key role in Institute life. Most of their time will be devoted to scientific projects. In addition, they are expected to actively participate in the coordination of workpackages, in the hosting of foreign researchers and in the organization of seminars and events (summer schools, conferences…). In exchange, these young researchers will benefit from an exceptional environment thanks to the presence of numerous leading international researchers, not to mention significant autonomy for their work. Montpellier hosts one of the most vibrant communities of biodiversity research in Europe with several research centers of excellence in the field. This positions is open for up to 3 years with a salary well above the French post-doc standards. Starting date is open to discussion.

 The application deadline is January 31, 2015.

Living in Montpellier: http://www.agropolis.org/english/guide/index.html

 

Contacts at WP2 « Evolutionary Genetics » :

 

Jean-Michel Marin : http://www.math.univ-montp2.fr/~marin/

François Rousset : http://www.isem.univ-montp2.fr/recherche/teams/evolutionary-genetics/staff/roussetfrancois/?lang=en

Vincent Ranwez : https://sites.google.com/site/ranwez/

Olivier Gascuel : http://www.lirmm.fr/~gascuel/

Submit my application : http://www.ibc-montpellier.fr/open-positions/young-investigators#wp2-evolution

ABC model choice by random forests

Posted in pictures, R, Statistics, Travel, University life with tags , , , , , , , , , , , , , on June 25, 2014 by xi'an

treerise6After more than a year of collaboration, meetings, simulations, delays, switches,  visits, more delays, more simulations, discussions, and a final marathon wrapping day last Friday, Jean-Michel Marin, Pierre Pudlo,  and I at last completed our latest collaboration on ABC, with the central arguments that (a) using random forests is a good tool for choosing the most appropriate model and (b) evaluating the posterior misclassification error rather than the posterior probability of a model is an appropriate paradigm shift. The paper has been co-signed with our population genetics colleagues, Jean-Marie Cornuet and Arnaud Estoup, as they provided helpful advice on the tools and on the genetic illustrations and as they plan to include those new tools in their future analyses and DIYABC software.  ABC model choice via random forests is now arXived and very soon to be submitted…

truePPOne scientific reason for this fairly long conception is that it took us several iterations to understand the intrinsic nature of the random forest tool and how it could be most naturally embedded in ABC schemes. We first imagined it as a filter from a set of summary statistics to a subset of significant statistics (hence the automated ABC advertised in some of my past or future talks!), with the additional appeal of an associated distance induced by the forest. However, we later realised that (a) further ABC steps were counterproductive once the model was selected by the random forest and (b) including more summary statistics was always beneficial to the performances of the forest and (c) the connections between (i) the true posterior probability of a model, (ii) the ABC version of this probability, (iii) the random forest version of the above, were at best very loose. The above picture is taken from the paper: it shows how the true and the ABC probabilities (do not) relate in the example of an MA(q) model… We thus had another round of discussions and experiments before deciding the unthinkable, namely to give up the attempts to approximate the posterior probability in this setting and to come up with another assessment of the uncertainty associated with the decision. This led us to propose to compute a posterior predictive error as the error assessment for ABC model choice. This is mostly a classification error but (a) it is based on the ABC posterior distribution rather than on the prior and (b) it does not require extra-computations when compared with other empirical measures such as cross-validation, while avoiding the sin of using the data twice!

last Big MC [seminar] before summer [June 19, 3pm]

Posted in pictures, Statistics, University life with tags , , , , , , , , , , , on June 17, 2014 by xi'an

crossing Rue Soufflot on my way to IHP from Vieux Campeur, March 28, 2013Last session of our Big’MC seminar at Institut Henri Poincaré this year, on Tuesday Thursday, June 19, with

Chris Holmes (Oxford) at 3pm on

Robust statistical decisions via re-weighted Monte Carlo samples

and Pierre Pudlo (iC3M, Université de Montpellier 2) at 4:15pm on [our joint work]

ABC and machine learning

trip to Montpellier

Posted in pictures, Statistics, Travel, University life, Wines with tags , , , , , , on February 27, 2014 by xi'an

IMG_2477Last week, I flew down to Montpellier for two days of work on ABC model choice with Jean-Michel Marin and Pierre Pudlo. Although we missed the COLT 2014 deadline, we are now close to completing this work that will propose a rather radical change in our advocacy of how ABC model choice should be conducted. We actually spent the second day on the wonderful campus of INRA at Montferrier-sur-Lez, just outside Montpellier, discussing of the implications of this approach with our friends at CBGP, Jean-Marie Cornuet and Arnaud Estoup. With possible impact on the DIYABC software. It was a very profitable trip (not mentioning tasting great Grés de Montpellier wine!) and I hope to manage completing the paper with Pierre during the next week in Banff. Unfortunately, when I came back to my train station, I found some idiots had a go at my bike and bent the back wheel which then needed to be replaced…

art brut

Posted in pictures, Travel with tags , , , , on February 8, 2014 by xi'an

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Saint Christol white & red

Posted in Travel, Wines with tags , , , , , , on September 20, 2013 by xi'an

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ABC for design

Posted in Statistics with tags , , , , , , , on August 30, 2013 by xi'an

I wrote a comment on this arXived paper on simulation based design that starts from Müller (1999) and gets an ABC perspective a while ago on my iPad when travelling to Montpellier and then forgot to download it…

Hainy, [Wener] Müller, and Wagner recently arXived a paper called “Likelihood-free Simulation-based Optimal Design“, paper which relies on ABC to construct optimal designs . Remember that [Peter] Müller (1999) uses a natural simulated annealing that is quite similar to our MAP [SAME] algorithm with Arnaud Doucet and Simon Godsill, relying on multiple versions of the data set to get to the maximum. The paper also builds upon our 2006 JASA paper with my then PhD student Billy Amzal, Eric Parent, and Frederic Bois, paper that took advantage of the then emerging particle methods to improve upon a static horizon target. While our method is sequential in that it pursues a moving target, it does not rely on the generic methodology developed by del Moral et al. (2006), where a backward kernel brings more stability to the moves. The paper also implements a version of our population Monte Carlo ABC algorithm (Beaumont et al., 2009), as a first step before an MCMC simulation. Overall, the paper sounds more like a review than like a strongly directive entry into ABC based design in that it remains quite generic. Not that I have specific suggestions, mind!, but I fear a realistic implementation (as opposed to the linear model used in the paper) would require a certain amount of calibration. There are missing references of recent papers using ABC for design, including some by Michael Stumpf I think.

I did not know about the Kuck et al. reference… Which is reproducing our 2006 approach within the del Moral framework. It uses a continuous temperature scale that I find artificial and not that useful, again a maybe superficial comment as I didn’t get very much into the paper … Just that integer powers lead to multiples of the sample and have a nice algorithmic counterpart.

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