pooling or not pooling

A pro-pooling opinion tribune, followed a few days later, by a collection of opinions on pooling PCR samples to absorb the overload in testing laboratories and produce results in a delay that is short enough for public health impacts.  Le Monde is taking sample pooling most seriously! This includes a link to an April article by Christian Grollier and Olivier Gossner (CREST) published in COVID economics (!), recalling the basics of sample pooling and citing a Technion experiment to show the approach is feasible in practice. With a recommended pool of 80 patients if the prevalence is 2%. And of 30 for a prevalence of 5%. Despite the approach being implemented in other countries, and considerable delays in analysing the PCR samples, the conclusion of the French public health authorities is that it is urgent to wait..!

4 Responses to “pooling or not pooling”

  1. Pooling is technically (I mean from biochemistry point of view) complex, subject to biases, and I guess that labs are not really prepared

  2. You might be interested in this Bayesian approach to pooling which has been proposed by Marco Cuturi: https://arxiv.org/abs/2004.12508

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