Archive for ABC model choice

ABC on brain networks

Posted in Books, pictures, Statistics, University life with tags , , , , , , , , , , , , , on April 16, 2021 by xi'an

Research Gate sent me an automated email pointing out a recent paper citing some of our ABC papers. The paper is written by Timothy West et al., neuroscientists in the UK, comparing models of Parkinsonian circuit dynamics. Using SMC-ABC. One novelty is the update of the tolerance by a fixed difference, unless the acceptance rate is too low, in which case the tolerance is reinitialised to a starting value.

“(…) the proposal density P(θ|D⁰) is formed from the accepted parameters sets. We use a density approximation to the marginals and a copula for the joint (…) [i.e.] a nonparametric estimation of the marginal densities overeach parameter [and] the t-copula(…) Data are transformed to the copula scale (unit-square) using the kernel density estimator of the cumulative distribution function of each parameter and then transformed to the joint space with the t-copula.”

The construct of the proposal is quite involved, as described in the above quote. The model choice approach is standard (à la Grelaud et al.) but uses the median distance as a tolerance.

“(…) test whether the ABC estimator will: a) yield parameter estimates that are unique to the data from which they have been optimized; and b) yield consistent estimation of parameters across multiple instances (…) test the face validity of the model comparison framework (…) [and] demonstrate the scalability of the optimization and model comparison framework.”

The paper runs a fairly extensive test of the above features, concluding that “the ABC optimized posteriors are consistent across multiple initializations and that the output is determined by differences in the underlying model generating the given data.” Concerning model comparison, the authors mix the ABC Bayes factor with a post-hoc analysis of divergence to discriminate against overfitting. And mention the potential impact of the summary statistics in the conclusion section, albeit briefly, and the remark that the statistics were “sufficient to recover known parameters” is not supporting their use for model comparison. The additional criticism of sampling strategies for approximating Bayes factors is somewhat irrelevant, the main issue with ABC model choice being a change of magnitude in the evidence.

“ABC has established itself as a key tool for parameter estimation in systems biology (…) but is yet to see wide adoption in systems neuroscience. It is known that ABC will not perform well under certain conditions (Sunnåker et al., 2013). Specifically, it has been shown that the
simplest form of ABC algorithm based upon an rejection-sampling approach is inefficient in the case where the prior densities lie far from the true posterior (…) This motivates the use of neurobiologically grounded models over phenomenological models where often the ranges of potential parameter values are unknown.”

locusts in a random forest

Posted in pictures, Statistics, University life with tags , , , , , , , , , , , on July 19, 2019 by xi'an

My friends from Montpellier, where I am visiting today, Arnaud Estoup, Jean-Michel Marin, and Louis Raynal, along with their co-authors, have recently posted on biorXiv a paper using ABC-RF (Random Forests) to analyse the divergence of two populations of desert locusts in Africa. (I actually first heard of their paper by an unsolicited email from one of these self-declared research aggregates.)

“…the present study is the first one using recently developed ABC-RF algorithms to carry out inferences about both scenario choice and parameter estimation, on a real multi-locus microsatellite dataset. It includes and illustrates three novelties in statistical analyses (…): model grouping analyses based on several key evolutionary events, assessment of the quality of predictions to evaluate the robustness of our inferences, and incorporation of previous information on the mutational setting of the used microsatellite markers”.

The construction of the competing models (or scenarios) is built upon data of past precipitations and desert evolution spanning several interglacial periods, back to the middle Pleistocene, concluding at a probable separation in the middle-late stages of the Holocene, which corresponds to the last transition from humid to arid conditions in the African continent. The probability of choosing the wrong model is exploited to determine which model(s) lead(s) to a posterior [ABC] probability lower than the corresponding prior probability, and only one scenario stands this test. As in previous ABC-RF implementations, the summary statistics are complemented by pure noise statistics in order to determine a barrier in the collection of statistics, even though those just above the noise elements (which often cluster together) may achieve better Gini importance by mere chance. An aspect of the paper that I particularly like is the discussion of the various prior modellings one can derive from existing information (or lack thereof) and the evaluation of the impact of these modellings on the resulting inference based on simulated pseudo-data.

over-confident about mis-specified models?

Posted in Books, pictures, Statistics, University life with tags , , , , , , , , , , , , , , , on April 30, 2019 by xi'an

Ziheng Yang and Tianqui Zhu published a paper in PNAS last year that criticises Bayesian posterior probabilities used in the comparison of models under misspecification as “overconfident”. The paper is written from a phylogeneticist point of view, rather than from a statistician’s perspective, as shown by the Editor in charge of the paper [although I thought that, after Steve Fienberg‘s intervention!, a statistician had to be involved in a submission relying on statistics!] a paper , but the analysis is rather problematic, at least seen through my own lenses… With no statistical novelty, apart from looking at the distribution of posterior probabilities in toy examples. The starting argument is that Bayesian model comparison is often reporting posterior probabilities in favour of a particular model that are close or even equal to 1.

“The Bayesian method is widely used to estimate species phylogenies using molecular sequence data. While it has long been noted to produce spuriously high posterior probabilities for trees or clades, the precise reasons for this over confidence are unknown. Here we characterize the behavior of Bayesian model selection when the compared models are misspecified and demonstrate that when the models are nearly equally wrong, the method exhibits unpleasant polarized behaviors,supporting one model with high confidence while rejecting others. This provides an explanation for the empirical observation of spuriously high posterior probabilities in molecular phylogenetics.”

The paper focus on the behaviour of posterior probabilities to strongly support a model against others when the sample size is large enough, “even when” all models are wrong, the argument being apparently that the correct output should be one of equal probability between models, or maybe a uniform distribution of these model probabilities over the probability simplex. Why should it be so?! The construction of the posterior probabilities is based on a meta-model that assumes the generating model to be part of a list of mutually exclusive models. It does not account for cases where “all models are wrong” or cases where “all models are right”. The reported probability is furthermore epistemic, in that it is relative to the measure defined by the prior modelling, not to a promise of a frequentist stabilisation in a ill-defined asymptotia. By which I mean that a 99.3% probability of model M¹ being “true”does not have a universal and objective meaning. (Moderation note: the high polarisation of posterior probabilities was instrumental in our investigation of model choice with ABC tools and in proposing instead error rates in ABC random forests.)

The notion that two models are equally wrong because they are both exactly at the same Kullback-Leibler distance from the generating process (when optimised over the parameter) is such a formal [or cartoonesque] notion that it does not make much sense. There is always one model that is slightly closer and eventually takes over. It is also bizarre that the argument does not account for the complexity of each model and the resulting (Occam’s razor) penalty. Even two models with a single parameter are not necessarily of intrinsic dimension one, as shown by DIC. And thus it is not a surprise if the posterior probability mostly favours one versus the other. In any case, an healthily sceptic approach to Bayesian model choice means looking at the behaviour of the procedure (Bayes factor, posterior probability, posterior predictive, mixture weight, &tc.) under various assumptions (model M¹, M², &tc.) to calibrate the numerical value, rather than taking it at face value. By which I do not mean a frequentist evaluation of this procedure. Actually, it is rather surprising that the authors of the PNAS paper do not jump on the case when the posterior probability of model M¹ say is uniformly distributed, since this would be a perfect setting when the posterior probability is a p-value. (This is also what happens to the bootstrapped version, see the last paragraph of the paper on p.1859, the year Darwin published his Origin of Species.)

a book and three chapters on ABC

Posted in Statistics with tags , , , , , , , , , , on January 9, 2019 by xi'an

In connection with our handbook on mixtures being published, here are three chapters I contributed to from the Handbook of ABC, edited by Scott Sisson, Yanan Fan, and Mark Beaumont:

6. Likelihood-free Model Choice, by J.-M. Marin, P. Pudlo, A. Estoup and C.P. Robert

12. Approximating the Likelihood in ABC, by  C. C. Drovandi, C. Grazian, K. Mengersen and C.P. Robert

17. Application of ABC to Infer about the Genetic History of Pygmy Hunter-Gatherers Populations from Western Central Africa, by A. Estoup, P. Verdu, J.-M. Marin, C. Robert, A. Dehne-Garcia, J.-M. Cornuet and P. Pudlo

ABC variable selection

Posted in Books, Mountains, pictures, Running, Statistics, Travel, University life with tags , , , , , , , , , , , on July 18, 2018 by xi'an

Prior to the ISBA 2018 meeting, Yi Liu, Veronika Ročková, and Yuexi Wang arXived a paper on relying ABC for finding relevant variables, which is a very original approach in that ABC is not as much the object as it is a tool. And which Veronika considered during her Susie Bayarri lecture at ISBA 2018. In other words, it is not about selecting summary variables for running ABC but quite the opposite, selecting variables in a non-linear model through an ABC step. I was going to separate the two selections into algorithmic and statistical selections, but it is more like projections in the observation and covariate spaces. With ABC still providing an appealing approach to approximate the marginal likelihood. Now, one may wonder at the relevance of ABC for variable selection, aka model choice, given our warning call of a few years ago. But the current paper does not require low-dimension summary statistics, hence avoids the difficulty with the “other” Bayes factor.

In the paper, the authors consider a spike-and… forest prior!, where the Bayesian CART selection of active covariates proceeds through a regression tree, selected covariates appearing in the tree and others not appearing. With a sparsity prior on the tree partitions and this new ABC approach to select the subset of active covariates. A specific feature is in splitting the data, one part to learn about the regression function, simulating from this function and comparing with the remainder of the data. The paper further establishes that ABC Bayesian Forests are consistent for variable selection.

“…we observe a curious empirical connection between π(θ|x,ε), obtained with ABC Bayesian Forests  and rescaled variable importances obtained with Random Forests.”

The difference with our ABC-RF model choice paper is that we select summary statistics [for classification] rather than covariates. For instance, in the current paper, simulation of pseudo-data will depend on the selected subset of covariates, meaning simulating a model index, and then generating the pseudo-data, acceptance being a function of the L² distance between data and pseudo-data. And then relying on all ABC simulations to find which variables are in more often than not to derive the median probability model of Barbieri and Berger (2004). Which does not work very well if implemented naïvely. Because of the immense size of the model space, it is quite hard to find pseudo-data close to actual data, resulting in either very high tolerance or very low acceptance. The authors get over this difficulty by a neat device that reminds me of fractional or intrinsic (pseudo-)Bayes factors in that the dataset is split into two parts, one that learns about the posterior given the model index and another one that simulates from this posterior to compare with the left-over data. Bringing simulations closer to the data. I do not remember seeing this trick before in ABC settings, but it is very neat, assuming the small data posterior can be simulated (which may be a fundamental reason for the trick to remain unused!). Note that the split varies at each iteration, which means there is no impact of ordering the observations.