Archive for AstraZeneca

journal of the [second] plague year [con’d]

Posted in Books, Kids, Mountains, pictures, Travel, University life with tags , , , , , , , , , , , , , , , , , , , , , , , , , on April 24, 2021 by xi'an

Read The Office of Gardens and Ponds (in French), by Didier Decoin [whom John l’Enfer I read more than forty years ago, with no lasting memories!], another random book found in the exchange section of our library!  While a pastiche of Japanese travel novels, the book is quite enjoyable and reminded me of our hike on the Kumano Kodō routes, two years ago. The tale takes place in 12th Century Japan and tells of the epic travel of a widow to the capital, Kyoto, carrying live carps for the gardens of the emperor. While some sections are somewhat encyclopedic on the culture of medieval Japan [and I thus wonder how Japanese readers have reacted to this pastiche], the scenario is rather subtle and the characters have depth, incl. the dead husband. The scene of the perfume competition is particularly well-imagined and worth reading on its own. I figure I will not bring the book back. (Warning: this book was voted a 2019 winner of the Bad Sex Award!). Also read Patti Smith’s Devotion, which was one of my Xmas presents. I had never read anything but Smith’s songs, since 1976 (!) with Horses, missing by little some of her concerts as on the week I was in Rimini… The book is quite light, and not only length-wise, made of two travel diaries in (to?) Paris and in (to?) Southern France, where she visits Camus’ house, and of a short story she writes on the train. While the diaries are mildly interesting, if a bit American-Tourist-in-Paris-cliché (like this insistence to find glamour in having breakfast at Café Flore!), the story comes as a disappointment, both for being unrealistic [in the negative sense] and for reproducing the old trope of the young orphan girl becoming the mistress of a much older man [to continue skating]. The connection with Estonia reminded me of Purge, by Sofi Oksanen, a powerful novel about the occupations of Estonia by Nazis and Soviet troups, an haunting novel of a different magnitude…

Made  soba noodles with the machine, resulting into shorte-than-life noodles, due to the high percentage of buckwheat flour in the dough, still quite enjoyable in a cold salad. Also cooked a roghan josh lamb shack, along with chapatis flavoured with radish leaves [no fire alarm this time] and a vegetable dahl whose recipe I found in Le Monde the same morn. Also took advantage of the few weeks with fresh and tender asparagus sold at the local market to make salads.

Watched a few episodes of Better than Us, Лучше (чем люди), a Russian science-fiction series set in a close future with humanoid robots replacing menial workers, until one rogue version turns uncontrollable, à la Blade Runner. There are appealing aspects to the story, besides the peep into a Russian series and the pleasure of listening to Russian, about the porous frontier between human and artificial intelligence. The scenario however quickly turns into a predictable loop and I eventually lost interest. Even faster did that happen with the Irregulars of Baker Street horror series, which I simply could not stand any further (and which connection with Holmes and Watson is most tenuous).

Having registered for a vaccination to the local pharmacy, I most got surprisingly called a few days later mid-afternoon to come at once for a shot of AstraZeneca, as they had a leftover dose. And a rising share of reluctant candidates for the vaccine!, despite David’s reassurances. I am unsure this shot was done early enough to get abroad for conferences or vacations in July, but it is one thing done anyway. With no side effect so far.

on Astra and clots

Posted in Books, Kids, pictures, Statistics with tags , , , , , , , , , , , , on March 16, 2021 by xi'an

A tribune this morning in The Guardian by David Spiegelhalter on having no evidence that the Oxford/AstraZeneca vaccine causes blood clots.

“It’s a common human tendency to attribute a causal effect between different events, even when there isn’t one present: we wash the car and the next day a bird relieves itself all over the bonnet. Typical.”

David sets the 30 throboembolic events among the 5 million people vaccinated with AstraZeneca in perpective of the expected 100 deep vein thromboses a week within such a population. Which coincides with the UK’s Medicines and Healthcare Products Regulatory Agency statement that the blood clots are in par with the expected numbers in the vaccinated population. (The part of the tribune about the yellow card reports, based on 10 million vaccinated people, reiterates the remark but may prove confusing to some!) As for hoping for a rational approach to the issue,  … we would need a different type of vaccine, far from being available! As demonstrated by the decision to temporarily stop vaccinating with this vaccine, causing sure additional deaths in the coming weeks.

“Will we ever be able to resist the urge to find causal relationships between different events? One way of doing this would be promoting the scientific method and ensuring everyone understands this basic principle. Testing a hypothesis helps us see which hunches or assumptions are correct and which aren’t. In this way, randomised trials have proved the effectiveness of some Covid treatments and saved vast numbers of lives, while also showing us that some overblown claims about treatments for Covid-19, such as hydroxychloroquine and convalescent plasma, were incorrect.”

probability that a vaccinated person is shielded from COVID-19?

Posted in Books, Statistics, Travel, University life with tags , , , , , , , , , , , , on March 10, 2021 by xi'an

Over my flight to Montpellier last week, I read an arXival on a Bayesian analysis of the vaccine efficiency. Whose full title is “What is the probability that a vaccinated person is shielded from Covid-19? A Bayesian MCMC based reanalysis of published data with emphasis on what should be reported as `efficacy'”, by Giulio D’Agostini and Alfredo Esposito. In short I was not particularly impressed.

“But the real point we wish to highlight, given the spread of distributions, is that we do not have enough data for drawing sound conclusion.”

The reason for this lack of enthusiasm on my side is that, while the authors’ criticism of an excessive precision in Pfizer, Moderna, or AstraZeneca press releases is appropriate, given the published confidence intervals are not claiming the same precision, a Bayesian reanalysis of the published outcome of their respective vaccine trial outcomes does not show much, simply because there is awfully little data, essentially two to four Binomial-like outcomes. Without further data, the modelling is one of a simple graph of Binomial observations, with two or three probability parameters, which results in a very standard Bayesian analysis that does depend on the modelling choices being made, from a highly unrealistic assumption of homogeneity throughout the population(s) tested for the vaccine(s), to a lack of hyperparameters that could have been shared between vaccinated populations. Parts of the arXival are unrelated and unnecessary, like the highly detailed MCMC algorithm for simulating the posterior (incl. JAGS code) to the reminiscence of Bayes’ and Laplace’s early rendering of inverse probability. (I find both interesting and revealing that arXiv, just like medRxiv, posts a warning on top of COVID related preprints.)