## Archive for design of experiments

## stained glass to go

Posted in pictures, University life with tags Caius & Gonville College, Cambridge, Cambridge colleges, controversies, design of experiments, DNA helix, eugenics, Francis Crick, latin square, Ronald Fisher, stained glass, Venn diagram on July 6, 2020 by xi'an## efficient acquisition rules for ABC

Posted in pictures, Statistics, University life with tags ABC, Banff, Bayesian inference, BIRS, design of experiments, discrepancy, Gaussian processes, NIPS 2014, posterior distribution on June 5, 2017 by xi'an**A** few weeks ago, Marko Järvenpää, Michael Gutmann, Aki Vehtari and Pekka Marttinen arXived a paper on sampling design for ABC that reminded me of presentations Michael gave at NIPS 2014 and in Banff last February. The main notion is that, when the simulation from the model is hugely expensive, random sampling does not make sense.

“While probabilistic modelling has been used to accelerate ABC inference, and strategies have been proposed for selecting which parameter to simulate next, little work has focused on trying to quantify the amount of uncertainty in the estimator of the ABC posterior density itself.”

The above question is obviously interesting, if already considered in the literature for it seems to focus on the Monte Carlo error in ABC, addressed for instance in Fearnhead and Prangle (2012), Li and Fearnhead (2016) and our paper with David Frazier, Gael Martin, and Judith Rousseau. With corresponding conditions on the tolerance and the number of simulations to relegate Monte Carlo error to a secondary level. And the additional remark that the (error free) ABC distribution itself is not the ultimate quantity of interest. Or the equivalent (?) one that ABC is actually an exact Bayesian method on a completed space.

The paper initially confused me for a section on the very general formulation of ABC posterior approximation and error in this approximation. And simulation design for minimising this error. It confused me as it sounded too vague but only for a while as the remaining sections appear to be independent. The operational concept of the paper is to assume that the discrepancy between observed and simulated data, when perceived as a random function of the parameter θ, is a Gaussian process [over the parameter space]. This modelling allows for a prediction of the discrepancy at a new value of θ, which can be chosen as maximising the variance of the likelihood approximation. Or more precisely of the acceptance probability. While the authors report improved estimation of the exact posterior, I find no intuition as to why this should be the case when focussing on the discrepancy, especially because small discrepancies are associated with parameters approximately generated from the posterior.

## can we trust computer simulations? [day #2]

Posted in Books, pictures, Statistics, Travel, University life with tags ABC, chaos, climate, climatic-skeptics, design of experiments, ecological models, Ecology, epistemology, equivalence test, ergodicity, Germany, Hannover, Herrenhausen Palace, manufactured solutions, philosophy of sciences, reproducible research, simulation, sociology, state space model, synthetic likelihood, validation, verification, WYSINWYG on July 13, 2015 by xi'an*“Sometimes the models are better than the data.” G. Krinner*

**S**econd day at the conference on building trust in computer simulations. Starting with a highly debated issue, climate change projections. Since so many criticisms are addressed to climate models as being not only wrong but also unverifiable. And uncheckable. As explained by Gerhart Krinner, the IPCC has developed methodologies to compare models and evaluate predictions. However, from what I understood, this validation does not say anything about the future, which is the part of the predictions that matters. And that is attacked by critics and feeds climatic-skeptics. Because it is so easy to argue against the homogeneity of the climate evolution and for “*what you’ve seen is not what you’ll get*“! (Even though climatic-skeptics are the least likely to use this time-heterogeneity argument, being convinced as they are of the lack of human impact over the climate.) The second talk was by Viktoria Radchuk about validation in ecology. Defined here as a test of predictions against independent data (and designs). And mentioning Simon Wood’s synthetic likelihood as the Bayesian reference for conducting model choice (as a synthetic likelihoods ratio). I had never thought of this use (found in Wood’s original paper) for synthetic likelihood, I feel a bit queasy about using a synthetic likelihood ratio as a genuine likelihood ratio. Which led to a lively discussion at the end of her talk. The next talk was about validation in economics by Matteo Richiardi, who discussed state-space models where the hidden state is observed through a summary statistic, perfect playground for ABC! But Matteo opted instead for a non-parametric approach that seems to increase imprecision and that I have never seen used in state-space models. The last part of the talk was about non-ergodic models, for which checking for validity becomes much more problematic, in my opinion. Unless one manages multiple observations of the non-ergodic path. Nicole Saam concluded this “Validation in…” morning with Validation in Sociology. With a more pessimistic approach to the possibility of finding a falsifying strategy, because of the vague nature of sociology models. For which data can never be fully informative. She illustrated the issue with an EU negotiation analysis. Where most hypotheses could hardly be tested.

“Bayesians persist with poor examples of randomness.” L. Smith

“Bayesians can be extremely reasonable.” L. Smith

The afternoon session was dedicated to methodology, mostly statistics! Andrew Robinson started with a talk on (frequentist) model validation. Called splitters and lumpers. Illustrated by a forest growth model. He went through traditional hypothesis tests like Neyman-Pearson’s that try to split between samples. And (bio)equivalence tests that take difference as the null. Using his equivalence R package. Then Leonard Smith took over [in a literal way!] from a sort-of-Bayesian perspective, in a work joint with Jim Berger and Gary Rosner on pragmatic Bayes which was mostly negative about Bayesian modelling. Introducing (to me) the compelling notion of structural model error as a representation of the inadequacy of the model. With illustrations from weather and climate models. His criticism of the Bayesian approach is that it cannot be holistic while pretending to be [my wording]. And being inadequate to measure model inadequacy, to the point of making prior choice meaningless. Funny enough, he went back to the ball dropping experiment David Higdon discussed at one JSM I attended a while ago, with the unexpected outcome that one ball did not make it to the bottom of the shaft. A more positive side was that posteriors are useful models but should not be interpreted from a probabilistic perspective. Move beyond probability was his final message. (For most of the talk, I misunderstood P(BS), the probability of a big surprise, for something else…) This was certainly the most provocative talk of the conference and the discussion could have gone on for the rest of day! Somewhat, Lenny was voluntarily provocative in piling the responsibility upon the Bayesian’s head for being overconfident and not accounting for the physicist’ limitations in modelling the phenomenon of interest. Next talk was by Edward Dougherty on methods used in biology. He separated within-model uncertainty from outside-model inadequacy. The within model part is mostly easy to agree upon. Even though difficulties in estimating parameters creates uncertainty classes of models. Especially because of being from a small data discipline. He analysed the impact of machine learning techniques like classification as being useless without prior knowledge. And argued in favour of the Bayesian minimum mean square error estimator. Which can also lead to a classifier. And experimental design. (Using MSE seems rather reductive when facing large dimensional parameters.) Last talk of the day was by Nicolas Becu, a geographer, with a surprising approach to validation via stakeholders. A priori not too enticing a name! The discussion was of a more philosophical nature, going back to (re)define validation against reality and imperfect models. And including social aspects of validation, e.g., reality being socially constructed. This led to the stakeholders, because a model is then a shared representation. Nicolas illustrated the construction by simulation “games” of a collective model in a community of Thai farmers and in a group of water users.

In a rather unique fashion, we also had an evening discussion on points we share and points we disagreed upon. After dinner (and wine), which did not help I fear! Bill Oberkampf mentioned the use of manufactured solutions to check code, which seemed very much related to physics. But then we got mired into the necessity of dividing between verification and validation. Which sounded very and too much engineering-like to me. Maybe because I do not usually integrate coding errors and algorithmic errors into my reasoning (verification)… Although sharing code and making it available makes a big difference. Or maybe because considering *all* models are wrong is neither part of my methodology (validation). This part ended up in a fairly pessimistic conclusion on the lack of trust in most published articles. At least in the biological sciences.

## robust Bayesian FDR control with Bayes factors [a reply]

Posted in Statistics, University life with tags Bayes factors, design of experiments, Dirichlet process, empirical Bayes methods, FDRs on January 17, 2014 by xi'an*(Following my earlier discussion of his paper, Xiaoquan Wen sent me this detailed reply.)*

I think it is appropriate to start my response to your comments by introducing a little bit of the background information on my research interest and the project itself: I consider myself as an applied statistician, not a theorist, and I am interested in developing theoretically sound and computationally efficient methods to solve practical problems. The FDR project originated from a practical application in genomics involving hypothesis testing. The details of this particular application can be found in this published paper, and the simulations in the manuscript are also designed for a similar context. In this application, the null model is trivially defined, however there exist finitely many alternative scenarios for each test. We proposed a Bayesian solution that handles this complex setting quite nicely: in brief, we chose to model each possible alternative scenario parametrically, and by taking advantage of Bayesian model averaging, Bayes factor naturally ended up as our test statistic. We had no problem in demonstrating the resulting Bayes factor is much more powerful than the existing approaches, even accounting for the prior (mis-)modeling for Bayes factors. However, in this genomics application, there are potentially tens of thousands of tests need to be simultaneously performed, and FDR control becomes necessary and challenging. Continue reading

## ABC for design

Posted in Statistics with tags ABC, arXiv, design of experiments, likelihood-free methods, Montpellier, population Monte Carlo, SAME algorithm, simulated annealing on August 30, 2013 by xi'an*I wrote a comment on this arXived paper on simulation based design that starts from Müller (1999) and gets an ABC perspective a while ago on my iPad when travelling to Montpellier and then forgot to download it…
*

**H**ainy, [Wener] Müller, and Wagner recently arXived a paper called “*Likelihood-free Simulation-based Optimal Design*“, paper which relies on ABC to construct optimal designs . Remember that [Peter] Müller (1999) uses a natural simulated annealing that is quite similar to our MAP [SAME] algorithm with Arnaud Doucet and Simon Godsill, relying on multiple versions of the data set to get to the maximum. The paper also builds upon our 2006 JASA paper with my then PhD student Billy Amzal, Eric Parent, and Frederic Bois, paper that took advantage of the then emerging particle methods to improve upon a static horizon target. While our method is sequential in that it pursues a moving target, it does not rely on the generic methodology developed by del Moral et al. (2006), where a backward kernel brings more stability to the moves. The paper also implements a version of our population Monte Carlo ABC algorithm (Beaumont et al., 2009), as a first step before an MCMC simulation. Overall, the paper sounds more like a review than like a strongly directive entry into ABC based design in that it remains quite generic. Not that I have specific suggestions, mind!, but I fear a realistic implementation (as opposed to the linear model used in the paper) would require a certain amount of calibration. There are missing references of recent papers using ABC for design, including some by Michael Stumpf I think.

**I** did not know about the Kuck et al. reference… Which is reproducing our 2006 approach within the del Moral framework. It uses a continuous temperature scale that I find artificial and not that useful, again a maybe superficial comment as I didn’t get very much into the paper … Just that integer powers lead to multiples of the sample and have a nice algorithmic counterpart.