Archive for England

learning and inference for medical discovery in Oxford [postdoc]

Posted in Kids, pictures, Statistics, Travel, University life with tags , , , , , , on January 10, 2017 by xi'an

[Here is a call for a two-year postdoc in Oxford sent to me by Arnaud Doucet. For those worried about moving to Britain, I think that, given the current pace—or lack thereof—of the negotiations with the EU, it is very likely that Britain will not have Brexited two years from now.]

Numerous medical problems ranging from screening to diagnosis to treatment of chronic diseases to  management of care in hospitals requires the development of novel statistical models and methods. These models and methods need to address the unique characteristics of medical data such as sampling bias, heterogeneity, non-stationarity, informative censoring etc. Existing state-of-the-art machine learning and statistics techniques often fail to exploit those characteristics. Additionally, the focus needs to be on probabilistic models which are
interpretable by the clinicians so that the inference results can be integrated within the medical-decision making.

We have access to unique datasets for clinical deterioration of patients in the hospital, for cancer screening, and for treatment of chronic diseases. Preliminary work has been tested and implemented at UCLA Medical Center, resulting in significantly management care in this hospital.

The successful applicant will be expected to develop new probabilistic models and learning methods inspired by these applications. The focus will be primarily on methodological and theoretical developments, and involve collaborating with Oxford researchers in machine learning, computational statistics and medicine to bring these developments to practice.

The post-doctoral researcher will be jointly supervised by Prof. Mihaela van der Schaar and Prof. Arnaud Doucet. Both of them have a strong track-record in advising PhD students and post-doctoral researchers who subsequently became successful academics in statistics, engineering sciences, computer science and economics. The position is for 2 years.

Great North Road [book review]

Posted in Books, Running, Travel with tags , , , , , , , , , , , , , , , on January 6, 2017 by xi'an

As I was unsure of the Internet connections and of the more than likely delays I would face during my trip to India, I went fishing for a massive novel on Amazon and eventually ordered Peter Hamilton’s Great North Road, a 1088 pages behemoth! I fear the book qualifies as space opera, with the conventional load of planet invasions, incomprehensible and infinitely wise aliens, gateways for instantaneous space travels, and sentient biospheres. But the core of the story is very, very, Earth-bound, with a detective story taking place in a future Newcastle that is not so distant from now in many ways. (Or even from the past as the 2012 book did not forecast Brexit…) With an occurrence of the town moor where I went running a few years ago.

The book is mostly well-designed, with a plot gripping enough to keep me hooked for Indian evenings in Kolkata and most of the flight back. I actually finished it just before landing in Paris. There is no true depth in the story, though, and the science fiction part is rather lame: a very long part of the detective plot is spent on the hunt for a taxi by an army of detectives, a task one would think should be delegated to a machine-learning algorithm and solved in a nano-second or so. The themes heavily borrow from those of classics like Avatar, Speaker for the Dead, Hyperion [very much Hyperion!], Alien… And from The Girl with the Dragon Tattoo for an hardcore heroin who is perfect at anything she undertakes.  Furthermore, the Earth at the centre of this extended universe is very close to its present version, with English style taxis, pub culture, and a geopolitic structure of the World pretty much unchanged. Plus main brands identical to currents ones (Apple, BMW, &tc), to the point it sounds like sponsored links! And no clue of a major climate change despite the continued use of fuel engines. Nonetheless, an easy read when stuck in an airport or a plane seat for several hours.

snapshot from Warwick [jatp]

Posted in pictures, Travel, University life with tags , , , , , on November 10, 2016 by xi'an

advanced computational methods for complex models in Biology [talk]

Posted in Books, pictures, Statistics, Travel, University life with tags , , , , , , , , , , , , on September 29, 2016 by xi'an

St Pancras. London, Jan. 26, 2012

Here are the slides of the presentation I gave at the EPSRC Advanced Computational methods for complex models in Biology at University College London, last week. Introducing random forests as proper summaries for both model choice and parameter estimation (with considerable overlap with earlier slides, obviously!). The other talks of that highly interesting day on computational Biology were mostly about ancestral graphs, using Wright-Fisher diffusions for coalescents, plus a comparison of expectation-propagation and ABC on a genealogy model by Mark Beaumont and the decision theoretic approach to HMM order estimation by Chris Holmes. In addition, it gave me the opportunity to come back to the Department of Statistics at UCL more than twenty years after my previous visit, at a time when my friend Costas Goutis was still there. And to realise it had moved from its historical premises years ago. (I wonder what happened to the two staircases built to reduce frictions between Fisher and Pearson if I remember correctly…)

contemporary issues in hypothesis testing

Posted in Statistics with tags , , , , , , , , , , , , , , , , , , on September 26, 2016 by xi'an

hipocontemptThis week [at Warwick], among other things, I attended the CRiSM workshop on hypothesis testing, giving the same talk as at ISBA last June. There was a most interesting and unusual talk by Nick Chater (from Warwick) about the psychological aspects of hypothesis testing, namely about the unnatural features of an hypothesis in everyday life, i.e., how far this formalism stands from human psychological functioning.  Or what we know about it. And then my Warwick colleague Tom Nichols explained how his recent work on permutation tests for fMRIs, published in PNAS, testing hypotheses on what should be null if real data and getting a high rate of false positives, got the medical imaging community all up in arms due to over-simplified reports in the media questioning the validity of 15 years of research on fMRI and the related 40,000 papers! For instance, some of the headings questioned the entire research in the area. Or transformed a software bug missing the boundary effects into a major flaw.  (See this podcast on Not So Standard Deviations for a thoughtful discussion on the issue.) One conclusion of this story is to be wary of assertions when submitting a hot story to journals with a substantial non-scientific readership! The afternoon talks were equally exciting, with Andrew explaining to us live from New York why he hates hypothesis testing and prefers model building. With the birthday model as an example. And David Draper gave an encompassing talk about the distinctions between inference and decision, proposing a Jaynes information criterion and illustrating it on Mendel‘s historical [and massaged!] pea dataset. The next morning, Jim Berger gave an overview on the frequentist properties of the Bayes factor, with in particular a novel [to me] upper bound on the Bayes factor associated with a p-value (Sellke, Bayarri and Berger, 2001)

B¹⁰(p) ≤ 1/-e p log p

with the specificity that B¹⁰(p) is not testing the original hypothesis [problem] but a substitute where the null is the hypothesis that p is uniformly distributed, versus a non-parametric alternative that p is more concentrated near zero. This reminded me of our PNAS paper on the impact of summary statistics upon Bayes factors. And of some forgotten reference studying Bayesian inference based solely on the p-value… It is too bad I had to rush back to Paris, as this made me miss the last talks of this fantastic workshop centred on maybe the most important aspect of statistics!

and another position in Oxford

Posted in Kids, pictures, Statistics, Travel, University life with tags , , , , , on July 20, 2016 by xi'an

St. Edmund Hall, Oxford, Feb. 01, 2016After a position in Bristol advertised a few days ago, I want to point out there also is a position opening in Oxford, Department of Statistics, in conjunction with a fellowship from University College. The deadline is August 26, 2016, and applicants should contact Professor Arnaud Doucet for details.

position in Bristol

Posted in Statistics, University life with tags , , , , , , on July 19, 2016 by xi'an

Clifton Bridge, Bristol, Sept. 24, 2012There is an opening for a Lecturer (i.e., assistant/associate professor) position in Statistical Science at the University of Bristol (School of Mathematics) with deadline August 7. Please contact Professor Christophe Andrieu for more details.