Archive for evolutionary biology

PCI Math Comp Biol gets live!

Posted in Books, Statistics, University life with tags , , , , , on March 5, 2020 by xi'an

A new Peer Community (PCI) preprint and postprint server is about to get live, with Mathematical & Computational Biology as its core interest. Thanks to the efforts of Amaury Lambert, Céline Scornavacca, and Eric Tannier. Following the earlier PCI Evol Biol (and my aborted attempt to start a PCI Comput Stats…). Although the funding and the core team are mostly French, the target is obviously international and editors from all backgrounds and specialties are most welcome to join as authors and reviewers!

locusts in a random forest

Posted in pictures, Statistics, University life with tags , , , , , , , , , , , on July 19, 2019 by xi'an

My friends from Montpellier, where I am visiting today, Arnaud Estoup, Jean-Michel Marin, and Louis Raynal, along with their co-authors, have recently posted on biorXiv a paper using ABC-RF (Random Forests) to analyse the divergence of two populations of desert locusts in Africa. (I actually first heard of their paper by an unsolicited email from one of these self-declared research aggregates.)

“…the present study is the first one using recently developed ABC-RF algorithms to carry out inferences about both scenario choice and parameter estimation, on a real multi-locus microsatellite dataset. It includes and illustrates three novelties in statistical analyses (…): model grouping analyses based on several key evolutionary events, assessment of the quality of predictions to evaluate the robustness of our inferences, and incorporation of previous information on the mutational setting of the used microsatellite markers”.

The construction of the competing models (or scenarios) is built upon data of past precipitations and desert evolution spanning several interglacial periods, back to the middle Pleistocene, concluding at a probable separation in the middle-late stages of the Holocene, which corresponds to the last transition from humid to arid conditions in the African continent. The probability of choosing the wrong model is exploited to determine which model(s) lead(s) to a posterior [ABC] probability lower than the corresponding prior probability, and only one scenario stands this test. As in previous ABC-RF implementations, the summary statistics are complemented by pure noise statistics in order to determine a barrier in the collection of statistics, even though those just above the noise elements (which often cluster together) may achieve better Gini importance by mere chance. An aspect of the paper that I particularly like is the discussion of the various prior modellings one can derive from existing information (or lack thereof) and the evaluation of the impact of these modellings on the resulting inference based on simulated pseudo-data.

peer community in evolutionary biology

Posted in Statistics with tags , , , , , , , on May 18, 2017 by xi'an

My friends (and co-authors) from Montpellier pointed out the existence of PCI Evolutionary Biology, which is a preprint and postprint validation forum [so far only] in the field of Evolutionary Biology. Authors of a preprint or of a published paper request a recommendation from the forum. If someone from the board finds the paper of interest, this person initiates a quick refereeing process with one or two referees and returns a review to the authors, with possible requests for modification, and if the lead reviewer is happy with the new version, the link to the paper and the reviews are published on PCI Evol Biol, which thus gives a stamp of validation to the contents in the paper. The paper can then be submitted for publication in any journal, as can be seen from the papers in the list.

This sounds like a great initiative and since PCI is calling for little brothers and sisters to PCI Evol Biol, I think we should try to build its equivalent in Statistics or maybe just Computational Statistics.