Archive for neurosciences

simulation-based inference for neuroscience [One World ABC seminar]

Posted in Books, pictures, Statistics, University life with tags , , , , , , , on April 26, 2021 by xi'an

The next One World ABC seminar will take place on Thursday at 11:30, UK time, and will broadcast a talk by Jakob Macke on Simulation-based inference for neuroscience. Here is the abstract

Neuroscience research makes extensive use of mechanistic models of neural dynamics — these models are often implemented through numerical simulators, requiring the use of simulation-based approaches to statistical inference. I will talk about our recent work on developing simulation based inference-methods using flexible density estimators parameterised with neural networks, our efforts on benchmarking these approaches, and applications to modelling problems in neuroscience.

Remember you need to register beforehand to receive the access code!

round-table on Bayes[ian[ism]]

Posted in Books, pictures, Statistics, University life with tags , , , , , , , , , , , , , , on March 7, 2017 by xi'an

In a [sort of] coincidence, shortly after writing my review on Le bayésianisme aujourd’hui, I got invited by the book editor, Isabelle Drouet, to take part in a round-table on Bayesianism in La Sorbonne. Which constituted the first seminar in the monthly series of the séminaire “Probabilités, Décision, Incertitude”. Invitation that I accepted and honoured by taking place in this public debate (if not dispute) on all [or most] things Bayes. Along with Paul Egré (CNRS, Institut Jean Nicod) and Pascal Pernot (CNRS, Laboratoire de chimie physique). And without a neuroscientist, who could not or would not attend.

While nothing earthshaking came out of the seminar, and certainly not from me!, it was interesting to hear of the perspectives of my philosophy+psychology and chemistry colleagues, the former explaining his path from classical to Bayesian testing—while mentioning trying to read the book Statistical rethinking reviewed a few months ago—and the later the difficulty to teach both colleagues and students the need for an assessment of uncertainty in measurements. And alluding to GUM, developed by the Bureau International des Poids et Mesures I visited last year. I tried to present my relativity viewpoints on the [relative] nature of the prior, to avoid the usual morass of debates on the nature and subjectivity of the prior, tried to explain Bayesian posteriors via ABC, mentioned examples from The Theorem that Would not Die, yet untranslated into French, and expressed reserves about the glorious future of Bayesian statistics as we know it. This seminar was fairly enjoyable, with none of the stress induced by the constraints of a radio-show. Just too bad it did not attract a wider audience!

le bayésianisme aujourd’hui [book review]

Posted in Books, pictures, Statistics, University life with tags , , , , , , , , , , , , , , , , , , on March 4, 2017 by xi'an

It is quite rare to see a book published in French about Bayesian statistics and even rarer to find one that connects philosophy of science, foundations of probability, statistics, and applications in neurosciences and artificial intelligence. Le bayésianisme aujourd’hui (Bayesianism today) was edited by Isabelle Drouet, a Reader in Philosophy at La Sorbonne. And includes a chapter of mine on the basics of Bayesian inference (à la Bayesian Choice), written in French like the rest of the book.

The title of the book is rather surprising (to me) as I had never heard the term Bayesianism mentioned before. As shown by this link, the term apparently exists. (Even though I dislike the sound of it!) The notion is one of a probabilistic structure of knowledge and learning, à la Poincaré. As described in the beginning of the book. But I fear the arguments minimising the subjectivity of the Bayesian approach should not be advanced, following my new stance on the relativity of probabilistic statements, if only because they are defensive and open the path all too easily to counterarguments. Similarly, the argument according to which the “Big Data” era makesp the impact of the prior negligible and paradoxically justifies the use of Bayesian methods is limited to the case of little Big Data, i.e., when the observations are more or less iid with a limited number of parameters. Not when the number of parameters explodes. Another set of arguments that I find both more modern and compelling [for being modern is not necessarily a plus!] is the ease with which the Bayesian framework allows for integrative and cooperative learning. Along with its ultimate modularity, since each component of the learning mechanism can be extracted and replaced with an alternative. Continue reading

sex, lies, & brain scans [not a book review]

Posted in Statistics with tags , , , , , , , on February 11, 2017 by xi'an

“Sahakian and Gottwald discuss the problem of “reverse inference” regrettably late in the book.”

In the book review section of Nature [Jan 12, 2017 issue], there was a long coverage of the book sex. lies, & brain scans: How fMRI Reveals What Really Goes on in our Minds, by Barbara J. Sahakian and Julia Gottwald. While I have not read the book (which is not even yet out on amazon), I found some mentions of associating brain patterns with criminal behaviour quite puzzling: “neuroimaging will probably be an imperfect predictor of criminal behaviour”. Actually, much more than puzzling, both frightening with its Minority Report prospects [once again quoted as a movie rather than Philip K. Dick’s novel!], and bordering the irrational, for associating breaking rules with a brain pattern. Of course this is just an impression from reading a book review and the attempts may be restricted to psychological diseases rather than attempt at social engineering and brain policing, but if this is the case, as suggested by the review, it is downright scary!

statistical challenges in neuroscience

Posted in Books, pictures, Statistics, Travel with tags , , , , , , on September 4, 2014 by xi'an

neuroYet another workshop around! Still at Warwick, organised by Simon Barthelmé, Nicolas Chopin and Adam Johansen  on the theme of statistical aspects of neuroscience. Being nearby I attended a few lectures today but most talks are more topical than my current interest in the matter, plus workshop fatigue starts to appear!, and hence I will keep a low attendance for the rest of the week to take advantage of my visit here to make some progress in my research and in the preparation of the teaching semester. (Maybe paradoxically I attended a non-neuroscience talk by listening to Richard Wilkinson’s coverage of ABC methods, with an interesting stress on meta-models and the link with computer experiments. Given that we are currently re-revising our paper with Matt Moore and Kerrie Mengersen (and now Chris Drovandi), I find interesting to see a sort of convergence in our community towards a re-re-interpretation of ABC as producing an approximation of the distribution of the summary statistic itself, rather than of the original data, using auxiliary or indirect or pseudo-models like Gaussian processes. (Making the link with Mark Girolami’s talk this morning.)