“The default parameter of KaKs_Calculator was set to estimate the Ka/Ks values, which means that the Ka/Ks value was the average of the output from 15 available algorithms comprising 7 original approximate methods and one maximum likelihood method.”
In their analysis of the philogenic evolution of the potato species, the Nature authors resort to a multiple analysis (à la EJ!) in the above sense, by averaging several results. I remain puzzled by the approach that treats all methods on an equal basis, without trying to ascertain precision and bias by X validation or other tools. (Approximate Bayesian Computing was not used as one of the methods.)
Xi'an's Og 