**A** recent arXived paper by Oliver J. Maclaren is asking this very question. And argue for a positive answer. One of the invoked sources is Murray Aitkin’s integrated likelihood book, which I criticised here and elsewhere. With the idea of the paper being that

“….there is an appropriate notion of integration over variables that takes likelihood functions to likelihood functions via maximization.”

Hmm…. The switch there is to replace addition with maximisation, probability with possibility, and… profile likelihood as marginal possibility under this new concept. I just do not see how adapting these concepts for the interpretation of the profile likelihood makes the latter more meaningful, since it still overwhelmingly does not result from a distribution density at an observed realisation of a random variable. This reminds me a paper I refereed quite a long while ago where the authors were using Schwarz’ theory of distributions to expand the notion of unbiasedness. With unclear consequences.